BCR anticorps

N° du produit ABIN6566471

L’anticorps Lapin Polyclonal anti-BCR a été validé pour WB et IHC. Il convient pour détecter BCR dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour BCR anticorps (ABIN6566471)

Antigène: BCR (Breakpoint Cluster Region (BCR))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-BCR anticorps

Purification: Affinity purification

Immunogène: Recombinant protein of human BCR

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000 IHC 1:50 - 1:100

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur BCR

Antigène: BCR (Breakpoint Cluster Region (BCR))

Autre désignation: BCR

Sujet:

Synonyms: ALL,bcr,BCR/ABL FUSION GENE,INCLUDED,BCR/FGFR1 chimera protein,BCR/FGFR1 FUSION GENE,INCLUDED,BCR/PDGFRA FUSION GENE,INCLUDED,BCR,BCR1,Breakpoint cluster region,Breakpoint cluster region protein,CML,D22S11,D22S662,FGFR1/BCR chimera protein,PHL,Renal carcinoma antigen NY-REN-26

Background: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire:

Observed_MW: 150kDa

Calculated_MW: 137kDa/142kDa

ID gène: 613

UniProt: P11274

Pathways: Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling